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Hisataka Shikama Selected Research

YM 53601

5/2003YM-53601, a novel squalene synthase inhibitor, suppresses lipogenic biosynthesis and lipid secretion in rodents.
3/2002Experimental model of escape phenomenon in hamsters and the effectiveness of YM-53601 in the model.

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Hisataka Shikama Research Topics

Disease

3Atherosclerosis
03/2005 - 01/2002
2Prostatic Neoplasms (Prostate Cancer)
11/2005 - 11/2005
2Myocardial Infarction
11/2004 - 11/2004
2Hypertrophy
11/2004 - 11/2004
2Heart Failure
11/2004 - 11/2004
2Hypercholesterolemia
05/2003 - 03/2002
1Pathologic Processes
11/2005
1X-Linked Bulbo-Spinal Atrophy
11/2005
1Hypoxia (Hypoxemia)
11/2004
1Body Weight (Weight, Body)
11/2004
1Fibrosis (Cirrhosis)
11/2004
1Pulmonary Hypertension
11/2004
1Infarction (Infarctions)
11/2004
1Pulmonary Heart Disease (Cor Pulmonale)
11/2004
1Right Ventricular Hypertrophy
11/2004
1Arthritis (Polyarthritis)
10/2004
1Osteoarthritis
10/2004
1Synovitis
10/2004
1Rheumatoid Arthritis
10/2004
1Granuloma
06/2004
1Carotid Artery Thrombosis
09/2003
1Thrombosis (Thrombus)
09/2003
1Hyperglycemia
03/2003
1Glucose Intolerance
07/2002

Drug/Important Bio-Agent (IBA)

2Androgen Receptors (Androgen Receptor)IBA
11/2005 - 11/2005
2AndrogensIBA
11/2005 - 11/2005
2Lipoprotein Lipase (Diacylglycerol Lipase)IBA
03/2005 - 06/2004
2CholesterolIBA
03/2005 - 05/2003
2Lipoproteins (Lipoprotein)IBA
03/2005 - 06/2004
2N- (6- methoxy- 5- (2- methoxyphenoxy)- 2- (pyrimidin- 2- yl)pyrimidin- 4- yl)- 2- phenylethenesulfonamide (YM598)IBA
11/2004 - 11/2004
2Endothelins (Endothelin)IBA
11/2004 - 11/2004
2CarrageenanIBA
10/2004 - 06/2004
2YM 53601IBA
05/2003 - 03/2002
2YM 440IBA
03/2003 - 07/2002
1Proteins (Proteins, Gene)FDA Link
11/2005
1Small Interfering RNA (siRNA)IBA
11/2005
1LigandsIBA
11/2005
1Biological ProductsIBA
11/2005
1salicylhydroxamic acid (SHAM)IBA
11/2004
1Bosentan (Tracleer)FDA Link
11/2004
1MonocrotalineIBA
11/2004
1Brain Natriuretic Peptide (Natrecor)FDA Link
11/2004
1Endothelin A ReceptorIBA
11/2004
1Proteoglycans (Proteoglycan)IBA
10/2004
1Matrix Metalloproteinases (MMPs)IBA
10/2004
1Pancreatic Elastase (Elastase)IBA
10/2004
1SolutionsIBA
10/2004
1low density lipoprotein inhibitorIBA
06/2004
1Apolipoproteins B (ApoB)IBA
06/2004
1Tissue Plasminogen Activator (Alteplase)FDA Link
09/2003
1Dihydrotachysterol (AT 10)IBA
09/2003
1YM-254890IBA
09/2003
1PPAR gammaIBA
03/2003
1Glucose (Dextrose)FDA LinkGeneric
07/2002
1GlycogenIBA
07/2002
1Lipoprotein(a)IBA
01/2002

Therapy/Procedure

1Therapeutics
11/2005
1Subcutaneous Injections
11/2004
1Ligation
11/2004